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Analysis of MGMT Promoter Methylation in Malignant Gliomas

Methylation analysis of the O6-­methylguanine DNA methyltransferase (MGMT) gene promoter from glioma tumor tissue is medically necessary for individuals who meet the following criteria:They have a tumor type consistent with high-­grade malignant glioma (eg, glioblastoma multiforme, anaplastic astrocytoma); and
Candidate for temozolomide therapy or radiotherapy; and
Methylation results will be used to direct their therapy choices.

MGMT promoter methylation analysis is investigational in situations that do not meet the above criteria.

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