Transoral incisionless fundoplication (ie, EsophyX) is considered investigational as a treatment of gastroesophageal reflux disease.
Transesophageal radiofrequency to create submucosal thermal lesions of the gastroesophageal junction (ie, Stretta procedure) is considered investigational as a treatment of gastroesophageal reflux disease.
Endoscopic submucosal implantation of a prosthesis or injection of a bulking agent (eg, polymethylmethacrylate beads, zirconium oxide spheres) is considered investigational as a treatment of gastroesophageal reflux disease.
