Novel assays that quantitatively measure total human epidermal growth factor receptor 2 (HER2) protein expression and homodimers have been developed to improve the accuracy and consistency of HER2 testing. However, the HERmark Breast Cancer Assay, the sole assay included in this review, was discontinued by the manufacturer in September 2020 (Monogram Biosciences, oral communication, November 2020).
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