Neutron Beam Radiotherapy

Neutron beam therapy is a form of radiotherapy that is used primarily for the treatment of unresectable or recurrent tumors. This policy does not address boron neutron capture therapy for cancer. Radiobiological principles demonstrate that radiation therapy using a neutron beam is associated with a higher linear energy transfer when compared to conventional photon or electron radiation therapy. This increased energy results in greater effectiveness. Some tumors appear to be more susceptible to the cytotoxic effect of neutrons. Studies show that local tumor control over 5 years was 75% in neutron use and 32% when compared to conventional photon and electron therapy. Acute toxicity was similar in all three therapy modalities although late severe toxicity, grade 3 and grade 4 is more prevalent with neutrons when compared to the other modalities. The modality using the neutron beam has also been shown to provide greater local control in salivary gland tumors in cases of advanced, recurrent, incomplete or inoperable resection. <a id="