Jemperli

Jemperli is a programmed death receptor-1 (PD-1)–blocking antibody indicated for: Endometrial Cancer • in combination with carboplatin and paclitaxel, followed by JEMPERLI as a single agent, for the treatment of adult patients with primary advanced or recurrent endometrial cancer (EC). • as a single agent for the treatment of adult patients with mismatch repair deficient (dMMR) recurrent or advanced EC, as determined by an FDA approved test, that has progressed on or following prior treatment with a platinum-containing regimen in any setting and are not candidates for curative surgery or radiation Mismatch Repair Deficient Recurrent or Advanced Solid Tumors • as a single agent for the treatment of adult patients with dMMR recurrent or advanced solid tumors, as determined by an FDA-approved test, that have progressed on or following prior treatment and who have no satisfactory alternative treatment options. This indication is approved under accelerated approval based on tumor response rate and durability of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s). Dostarlimab-gxly (Jemperli) is a monoclonal antibody that works by targeting the programmed death-1 receptor (PD-1), which is involved in T-cell immune surveillance of tumors. Binding of the PD-1 receptor results in blockade of the PD-1 and PD-2 ligands which generates an anti-tumor immune response and decreased tumor growth. Mismatch repair deficient (dMMR) tumors are expressed in various cancers and have high mutation rates due to the inability to repair DNA replication errors. These tumors have higher levels of neoantigens and have been found to be responsive to PD-1 targeted immunotherapy. <a id="