Jak2 And Mpl, Testing For Myeloproliferative Neoplasms

Somatic (acquired) genetic variants in JAK2, MPL, and CALR genes have been implicated as the underlying molecular genetic drivers for the pathogenesis of myeloproliferative neoplasms (MPN). This evidence review addresses the use of genetic testing for JAK2, MPL, and CALR genes for diagnosis, prognosis, and treatment selection of patients with MPN.