Terapia con interferón

Interferon is one of about 20 naturally occurring proteins. Three classes of interferons have been identified; alpha, beta and gamma. Each of these classes is chemically unique, distinct, synthesized and released by different groups of cells. Each one has a specific function. Interferons play a very important part in the immune system. Animal and preclinical studies in human tissues suggest that interferons have antiviral, antiproliferative, antiangiogenic, immunomodulatory, and gene regulatory properties. Its application in clinical oncology is based on the following observations: • Evidence suggests that interferons have a direct antiproliferative effect on some cancer cells. • Increase cycle length and deplete essential intracellular metabolites, promoting cell lysis or destruction. • The proposed mechanism of action is the activation of the expression of surface antigens. • Macrophage activity, lymphocyte cytotoxicity, and induction of antibodies to tumor cells are enhanced. <a id="