Human Leukocyte Antigen Testing for Celiac Disease

HLA-DQ2 and HLA-DQ8 testing may be considered medically necessary to rule out celiac disease in:

patients with persistent symptoms despite negative serology and histology; or

patients with discordant serologic and histologic (biopsy) findings.

HLA-DQ2 and HLA-DQ8 testing for celiac disease is considered investigational in all other situations.