Genetic Testing for PTEN Hamartoma Tumor Syndrome

Genetic testing for PTEN may be considered medically necessary to confirm the diagnosis when a patient has clinical signs of a PTEN hamartoma tumor syndrome.

Targeted genetic testing for a PTEN familial variant may be considered medically necessary in a first-degree relative of a proband with a known PTEN pathogenic variant.

Genetic testing for PTEN is considered investigational for all other indications.