Vedolizumab

Vedolizumab is a recombinant human IgG1 monoclonal antibody produced in Chinese hamster ovaries. It binds to a human alpha 4 beta 7 integrin site and blocks the interaction of this integrin with mucosal addressin adhesion molecules. This inhibits the migration of memory T-lymphocytes across the endothelium into the inflamed gastrointestinal tissue. This interaction is thought to be an important contributor to the chronic inflammation of ulcerative colitis and Crohn's disease. <a id="