Botulinum Toxin

Botulinum is a family of toxins produced by the anaerobic organism Clostridia botulinum. Multiple formulations of botulinum toxin have been approved by the U.S. Food and Drug Administration (FDA). Labeled indications of these agents differ. Botulinum toxin products are also used for a range of off-label indications. The scope of the evidence review is limited to off-label use of 5 botulinum toxin agents currently available and approved by the FDA for medical use. These include onabotulinumtoxinA (Botox), abobotulinumtoxinA (Dysport), incobotulinumtoxinA (Xeomin), rimabotulinumtoxinB (Myobloc), and daxibotulinumtoxinA (Daxxify).