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Bone Morphogenetic Protein

Use of recombinant human bone morphogenetic protein-2 (Infuse™) may be considered medically necessary in skeletally mature patients:For anterior lumbar interbody fusion procedures when the use of autograft is not feasible;

For instrumented posterolateral intertransverse spinal fusion procedures when the use of autograft is not feasible;

For the treatment of acute, open fracture of the tibial shaft, when the use of autograft is not feasible.

Use of recombinant human bone morphogenetic protein-2 is considered not medically necessary for all other indications, including but not limited to spinal fusion when the use of autograft is feasible and craniomaxillofacial surgery.

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