Use of recombinant human bone morphogenetic protein-2 (Infuse™) may be considered medically necessary in skeletally mature individuals:
For anterior lumbar interbody fusion procedures when the use of autograft is not feasible;
For instrumented posterolateral intertransverse spinal fusion procedures when the use of autograft is not feasible;
For the treatment of acute, open fracture of the tibial shaft, when the use of autograft is not feasible.
Use of recombinant human bone morphogenetic protein-2 is considered investigational for all other indications, including but not limited to spinal fusion when the use of autograft is feasible and craniomaxillofacial surgery.
